中文簡(jiǎn)介

隨著RNA替代RNA處理，調(diào)節(jié)RNA和RNA介導(dǎo)的酶促機(jī)制等現(xiàn)象對(duì)細(xì)胞中基因表達(dá)調(diào)控的重要性的出現(xiàn)，以及RNA對(duì)疾病發(fā)病機(jī)制和正常發(fā)育的貢獻(xiàn)的認(rèn)識(shí)，已經(jīng)成為了解所有生命科學(xué)學(xué)科必不可少的RNA生物學(xué)領(lǐng)域。 WIREs RNA的目標(biāo)是為這個(gè)有趣且不斷發(fā)展的領(lǐng)域提供全面，最新和連貫的報(bào)道，為RNA專家和跨學(xué)科研究人員提供框架，不僅可以獲得RNA生物學(xué)領(lǐng)域的觀點(diǎn)，而且可以產(chǎn)生新的見解和應(yīng)用程序。主要議題包括：RNA結(jié)構(gòu)和動(dòng)力學(xué); RNA進(jìn)化和基因組學(xué);基于RNA的催化; RNA與蛋白質(zhì)和其他分子的相互作用;翻譯; RNA加工; RNA出口/本地化; RNA轉(zhuǎn)換和監(jiān)測(cè);調(diào)節(jié)RNA / RNAi /核糖開關(guān);疾病與發(fā)展中的RNA;和RNA方法。

英文簡(jiǎn)介

The emergence of the importance of such phenomena as alternative RNA processing, regulatory RNAs, and RNA-mediated enzymatic mechanisms to the regulation of gene expression in cells, along with the recognition of the contributions of RNA to disease pathogenesis and normal development, have made an understanding of the field of RNA biology essential to all life science disciplines. It is the goal of WIREs RNA to provide comprehensive, up-to-date, and coherent coverage of this interesting and growing field, providing a framework for both RNA experts and interdisciplinary researchers to not only gain perspective in areas of RNA biology, but to generate new insights and applications as well. Major topics to be covered are: RNA Structure and Dynamics; RNA Evolution and Genomics; RNA-Based Catalysis; RNA Interactions with Proteins and Other Molecules; Translation; RNA Processing; RNA Export/Localization; RNA Turnover and Surveillance; Regulatory RNAs/RNAi/Riboswitches; RNA in Disease and Development; and RNA Methods.