中文簡介

《蛋白質(zhì)科學(xué)》是蛋白質(zhì)學(xué)會的旗艦期刊，為發(fā)表有關(guān)蛋白質(zhì)分子所有科學(xué)方面的原始報(bào)告提供了一個(gè)國際論壇。該雜志發(fā)表了來自世界各地的頂尖科學(xué)家的論文，報(bào)告了在最廣義上對蛋白質(zhì)的理解方面的進(jìn)展。蛋白質(zhì)科學(xué)的目標(biāo)是通過跨越既定的學(xué)科界限，聚焦于“以蛋白質(zhì)為中心”的科學(xué)，從而統(tǒng)一這一領(lǐng)域。該雜志包括蛋白質(zhì)的結(jié)構(gòu)、功能和生化意義，它們在分子和細(xì)胞生物學(xué)、遺傳學(xué)和進(jìn)化中的作用，以及它們的調(diào)控和作用機(jī)制。特別感興趣的題目包括但不限于:■蛋白質(zhì)結(jié)構(gòu)和用化學(xué)、生物物理和重組方法確定蛋白質(zhì)結(jié)構(gòu)的策略■肽■蛋白質(zhì)域■蛋白質(zhì)折疊和分子動力學(xué)新型隔離程序■酶的作用和調(diào)節(jié)■蛋白質(zhì)與核酸、脂類、配體和其他蛋白質(zhì)的相互作用■受體介導(dǎo)的信號轉(zhuǎn)導(dǎo)等跨膜現(xiàn)象■蛋白質(zhì)在復(fù)制、超分子組裝、免疫反應(yīng)、發(fā)育等生物學(xué)過程中的功能■蛋白質(zhì)的轉(zhuǎn)運(yùn)、合成和分選■蛋白質(zhì)的識別、定位和信號轉(zhuǎn)導(dǎo)除了上述的研究技術(shù)，該雜志還將發(fā)表以下以蛋白質(zhì)為中心的研究結(jié)果:■測序、修飾和質(zhì)譜分析■cDNA、誘變和克隆■計(jì)算分析■分離與表征■熱力學(xué)和流體動力學(xué)■動力學(xué)■平衡現(xiàn)象蛋白質(zhì)科學(xué)出版完整的原始研究論文，以及評論和書評?；貞?僅憑邀請)是一種歷史回顧，旨在概述蛋白質(zhì)科學(xué)中某個(gè)特定主題是如何發(fā)展起來的。有一個(gè)特別部分，供記錄，其中載有關(guān)于該領(lǐng)域最近發(fā)展情況的簡要參考報(bào)告(即;本節(jié)可能突出顯示一個(gè)新的蛋白質(zhì)序列或報(bào)告一個(gè)新的蛋白質(zhì)結(jié)構(gòu)和/或功能)。審查(僅邀請)的目的是使一般讀者熟悉迅速發(fā)展的當(dāng)前感興趣的主題的現(xiàn)狀和未來趨勢。

英文簡介

Protein Science, the flagship journal of The Protein Society, serves an international forum for publishing original reports on all scientific aspects of protein molecules. The Journal publishes papers by leading scientists from all over the world that report on advances in the understanding of proteins in the broadest sense. Protein Science aims to unify this field by cutting across established disciplinary lines and focusing on “protein-centered” science.The Journal encompasses the structure, function, and biochemical significance of proteins, their role in molecular and cell biology, genetics, and evolution, and their regulation and mechanisms of action. Topics of particular interest include, but are not limited to: ■ Structure of proteins and strategies of determining protein structure by chemical, biophysical, and recombinant methods ■ Peptides ■ Protein domains ■ Protein folding and molecular dynamics ■ Novel isolation procedures ■ Enzyme action and regulation ■ Interactions of proteins with nucleic acids, lipids, ligands, and other proteins ■ Receptor-mediated signal transduction and other trans-membrane phenomena ■ The functions of proteins in replication, supramolecular assembly, immune reactions, development, and other biological processes ■ Protein trafficking, synthesis and sorting ■ Recognition, localization and signaling of proteinsIn addition to the investigative techniques aforementioned, the Journal will publish results of protein-centered work involving: ■ Sequencing, modification, and mass spectrometry ■ cDNA, mutagenesis and cloning ■ Computational analysis ■ Isolation and characterization ■ Thermodynamics and hydrodynamics ■ Kinetics ■ Equilibrium phenomenaProtein Science publishes full-length original research papers as well as reviews and book reviews. Recollections (by invitation only) are historical reviews that are intended to give an overview of how a particular topic in the science of proteins has developed. A special section, For the Record, features brief refereed reports of recent developments in the field (i.e.; this section may highlight a new protein sequence or report a new protein structure and/or function). Reviews (by invitation only) are intended to familiarize the general reader with the current status and future trends of rapidly evolving topics of current interest.