中文簡介

由生物醫(yī)學(xué)中心出版。ISSN:1742-2094?！渡窠?jīng)炎癥雜志》是一份開放獲取、同行評議的在線雜志，關(guān)注中樞神經(jīng)系統(tǒng)的先天免疫反應(yīng)，包括小膠質(zhì)細(xì)胞、星形膠質(zhì)細(xì)胞、細(xì)胞因子、趨化因子和相關(guān)的分子過程?！吧窠?jīng)炎癥”是對中樞神經(jīng)系統(tǒng)的小膠質(zhì)細(xì)胞和星形細(xì)胞反應(yīng)和行為具有基本炎癥樣特征的一種概括，這些反應(yīng)是多種神經(jīng)系統(tǒng)疾病的發(fā)病機(jī)制和進(jìn)展的核心。這個(gè)想法徹底改變了我們對阿爾茨海默氏癥的理解，它起源于阿爾茨海默氏癥，現(xiàn)在已經(jīng)應(yīng)用于其他神經(jīng)退行性疾病，缺血性/毒性疾病，甚至是正常的大腦發(fā)育。神經(jīng)炎癥包括一系列復(fù)雜的細(xì)胞反應(yīng)，包括小膠質(zhì)細(xì)胞和星形膠質(zhì)細(xì)胞、細(xì)胞因子和趨化因子、補(bǔ)體蛋白、急性期蛋白、氧化損傷和相關(guān)的分子過程。神經(jīng)炎癥是一個(gè)迅速發(fā)展的新領(lǐng)域，它徹底改變了我們對慢性神經(jīng)疾病的認(rèn)識。這一領(lǐng)域的研究人員已成長為涵蓋許多不同領(lǐng)域的背景，包括病理學(xué)、生物化學(xué)、分子生物學(xué)、遺傳學(xué)、臨床醫(yī)學(xué)和流行病學(xué)。這一領(lǐng)域的重要貢獻(xiàn)來自于對人群、患者、死后組織、動物模型和體外系統(tǒng)的研究。神經(jīng)炎癥雜志將集中研究常見的致病過程，并為該領(lǐng)域的綜合評論提供一個(gè)論壇。

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英文簡介

Published by BioMed Central. ISSN: 1742-2094.Journal of Neuroinflammation is an Open Access, peer-reviewed online journal that focuses on innate immunological responses of the central nervous system, involving microglia, astrocytes, cytokines, chemokines, and related molecular processes. 'Neuroinflammation' is an encapsulization of the idea that microglial and astrocytic responses and actions in the central nervous system have a fundamentally inflammation-like character, and that these responses are central to the pathogenesis and progression of a wide variety of neurological disorders. This idea has revolutionized our understanding of Alzheimer's disease, where it originated, and now has applications to other neurodegenerative diseases, to ischemic/toxic diseases, and even to normal brain development. Neuroinflammation incorporates a wide spectrum of complex cellular responses that include microglia and astrocytes, cytokines and chemokines, complement proteins, acute phase proteins, oxidative injury, and related molecular processes. Neuroinflammation is a new and rapidly expanding field that has revolutionized our understanding of chronic neurological diseases. This field has grown to encompass researchers with backgrounds in many diverse fields, including pathology, biochemistry, molecular biology, genetics, clinical medicine, and epidemiology. Important contributions to this field have come from work with populations, with patients, with postmortem tissues, with animal models, and with in vitro systems. The Journal of Neuroinflammation will bring together work focusing on common pathogenic processes, and provide a forum for integrative reviews and commentaries on this field.