中文簡(jiǎn)介

該雜志的主要目的是發(fā)表關(guān)于分子不對(duì)稱(chēng)在生物活性和非生物活性分子的藥理、生物和化學(xué)性質(zhì)方面的作用的科學(xué)工作。藥物、殺蟲(chóng)劑和其他外源性藥物將是主要的研究對(duì)象。將發(fā)表手性分子的化學(xué)(生化學(xué)制備、合成和分析)、藥理學(xué)、臨床藥理學(xué)、毒理學(xué)等生物學(xué)方面的論文。要覆蓋的主題包括立體定向合成立體選擇分析制備的手性分子分離手性對(duì)藥物動(dòng)力學(xué)的影響(吸收分布蛋白結(jié)合生物轉(zhuǎn)化等)手性的影響在藥效學(xué)(drug-receptor交互藥理學(xué)和毒理學(xué)活動(dòng))和手性對(duì)臨床藥理學(xué)(治療指數(shù)的影響和應(yīng)對(duì)生物利用度藥品不良反應(yīng)藥物之間交互)。還將發(fā)表關(guān)于手性化合物開(kāi)發(fā)、檢測(cè)和銷(xiāo)售的管制和法律方面的論文。除了原始的研究論文，該雜志還將發(fā)表簡(jiǎn)短的評(píng)論、簡(jiǎn)短的交流和會(huì)議報(bào)告。書(shū)評(píng)也會(huì)出現(xiàn)。

投稿網(wǎng)址：http://mc.manuscriptcentral.com/chir

英文簡(jiǎn)介

The main aim of the journal is to publish scientific work on the role of molecular asymmetry in both biologically active and non-biologically active molecules in respect to their pharmacological biological and chemical properties. Drugs pesticides and other xenobiotics will be a major interest. Papers on the chemistry (physiochemical preparative synthetic and analytical) pharmacology clinical pharmacology toxicology and other biological aspects of chiral molecules will be published. Among the topics to be covered are stereospecific synthesis stereoselective analysis preparative separation of chiral molecules the influence of chirality on pharmacokinetics (absorption distribution protein binding biotransformation etc.) the influence of chirality on pharmacodynamics (drug-receptor interactions pharmacological and toxicological activity) and the influence of chirality on clinical pharmacology (therapeutic index and response bioavailability adverse drug reactions drug-drug interactions). Papers will also be published on regulatory and legal aspects in the development testing and marketing of chiral compounds. In addition to original research papers the journal will publish brief reviews short communications and conference reports. Book reviews will also appear.