中文簡介

該雜志的主要目的是發(fā)表關于分子不對稱在生物活性和非生物活性分子的藥理、生物和化學性質方面的作用的科學工作。藥物、殺蟲劑和其他外源性藥物將是主要的研究對象。將發(fā)表手性分子的化學(生化學制備、合成和分析)、藥理學、臨床藥理學、毒理學等生物學方面的論文。要覆蓋的主題包括立體定向合成立體選擇分析制備的手性分子分離手性對藥物動力學的影響(吸收分布蛋白結合生物轉化等)手性的影響在藥效學(drug-receptor交互藥理學和毒理學活動)和手性對臨床藥理學(治療指數(shù)的影響和應對生物利用度藥品不良反應藥物之間交互)。還將發(fā)表關于手性化合物開發(fā)、檢測和銷售的管制和法律方面的論文。除了原始的研究論文，該雜志還將發(fā)表簡短的評論、簡短的交流和會議報告。書評也會出現(xiàn)。

投稿網(wǎng)址：http://mc.manuscriptcentral.com/chir

英文簡介

The main aim of the journal is to publish scientific work on the role of molecular asymmetry in both biologically active and non-biologically active molecules in respect to their pharmacological biological and chemical properties. Drugs pesticides and other xenobiotics will be a major interest. Papers on the chemistry (physiochemical preparative synthetic and analytical) pharmacology clinical pharmacology toxicology and other biological aspects of chiral molecules will be published. Among the topics to be covered are stereospecific synthesis stereoselective analysis preparative separation of chiral molecules the influence of chirality on pharmacokinetics (absorption distribution protein binding biotransformation etc.) the influence of chirality on pharmacodynamics (drug-receptor interactions pharmacological and toxicological activity) and the influence of chirality on clinical pharmacology (therapeutic index and response bioavailability adverse drug reactions drug-drug interactions). Papers will also be published on regulatory and legal aspects in the development testing and marketing of chiral compounds. In addition to original research papers the journal will publish brief reviews short communications and conference reports. Book reviews will also appear.