中文簡介

當(dāng)代生命科學(xué)的許多研究致力于分子尺度上對(duì)生物過程的理解，特別是細(xì)胞效應(yīng)因子(包括蛋白質(zhì))水平的動(dòng)態(tài)變化、修飾和相互作用。分子生物科學(xué)前沿為基礎(chǔ)研究和應(yīng)用研究提供了一個(gè)國際出版平臺(tái);我們鼓勵(lì)在生物學(xué)的成熟和新興領(lǐng)域做出貢獻(xiàn)。為此，該雜志借鑒了結(jié)構(gòu)生物學(xué)、酶學(xué)、生物化學(xué)和生物物理學(xué)等經(jīng)驗(yàn)學(xué)科，利用了技術(shù)進(jìn)步，使代謝組學(xué)和蛋白質(zhì)組學(xué)測量能夠大規(guī)模并行進(jìn)行，并開發(fā)了強(qiáng)大和創(chuàng)新的計(jì)算生物學(xué)策略。我們還認(rèn)識(shí)到醫(yī)學(xué)和技術(shù)的影響，歡迎在分子遺傳學(xué)、分子診斷和治療學(xué)以及納米技術(shù)方面的研究。除了有趣的新發(fā)現(xiàn)、新技術(shù)和新應(yīng)用，分子生物科學(xué)前沿還將考慮新的可測試假設(shè)，以激發(fā)不同的觀點(diǎn)和促進(jìn)科學(xué)對(duì)話。有機(jī)硅、體外和體內(nèi)方法的整合將有益于生命科學(xué)各個(gè)領(lǐng)域的努力。我們的最終目標(biāo)是全面闡明調(diào)控蛋白質(zhì)、核酸、碳水化合物、脂類和小代謝產(chǎn)物的分子機(jī)制。

英文簡介

Much of contemporary investigation in the life sciences is devoted to the molecular-scale understanding of biological processes — in particular, dynamic alterations in the levels, modifications, and interactions of cellular effectors, including proteins. Frontiers in Molecular Biosciences offers an international publication platform for basic as well as applied research; we encourage contributions spanning both established and emerging areas of biology.To this end, the journal draws from empirical disciplines such as structural biology, enzymology, biochemistry, and biophysics, capitalizing as well on the technological advancements that have enabled metabolomics and proteomics measurements in massively parallel throughput, and the development of robust and innovative computational biology strategies. We also recognize influences from medicine and technology, welcoming studies in molecular genetics, molecular diagnostics and therapeutics, and nanotechnology.In addition to interesting new findings, techniques, and applications, Frontiers in Molecular Biosciences will consider new testable hypotheses to inspire different perspectives and stimulate scientific dialogue. The integration of in silico, in vitro, and in vivo approaches will benefit endeavors across all domains of the life sciences.Our ultimate objective is the comprehensive illustration of the molecular mechanisms regulating proteins, nucleic acids, carbohydrates, lipids, and small metabolites in organisms across all branches of life.